Radiesse is an FDA approved synthetic dermal injectable filler made of calcium hydroxyl apatite microspheres in a water-based gel. Radiesse is designed to correct/augment moderate to deep facial frown lines and wrinkles. It is especially effective for the folds around the nose and mouth. Skin testing is not required. The desired effect should last 12 to 16 months, but will slowly dissipate over that period of time.